(Apocynaceae) Cryptolepis dubia M.R.Almeida

Local name(s): ເຄືອ ເອັນ ອ່ອນ (kheua en onh)

Medicinal use(s): Used for treatment of nervous breakdown.

Part used: vine stem

Field characters: Vine, flowers greenish yellow to pale yellow, latex milky white.

Locality: Xieng Khoang Province, Kham District, Kham Medicinal Biodiversity Preserve, 15 km from Kham town.

Habitat: Broadleaved evergreen submontane forest. Edge of forest along road. Rare occurrence.

Altitude: 1130 m asl

Collector(s): D.D. Soejarto, K. Sydara, M. Xayvue

Collection number: DDS 14971

Collection date: May 16, 2014

Additional information:  

Synonyms, images, taxonomic description:  

Useful references:

Henkin JM, Sydara K, Xayvue M, et al. (2017). Revisiting the linkage between ethnomedical use and development of new medicines: A novel plant collection strategy towards the discovery of anticancer agents. Journal of Medicinal Plant Research 2017, 11(40), 621-634. https://doi.org/10.5897/JMPR2017.6485

Ren Y, Kaweesa EN, Tian L, et al. The Cytotoxic Cardiac Glycoside (−)-Cryptanoside A from the Stems of Cryptolepis dubia and Its Molecular Targets. Journal of Natural Products 2023 86 (6). 14. DOI: 10.1021/acs.jnatprod.3c00094

Ren Y, Kaweesa EN, Henkin JH, et al. Cytotoxic leuconoxine-type diazaspiroindole alkaloids isolated from Cryptolepis dubia. Bioorganic & Medicinal Chemistry Letters 2024, volume 101, 129650. ISSN 0960-894X. https://doi.org/10.1016/j.bmcl.2024.129650. 

Venkateswara R, Narendra N, Viswamitra MA, et al. Cryptosin, a cardenolide from the leaves of Cryptolepis buchanani. Phytochemistry 1989, volume 28, issue 4, pages 1203-1205. ISSN 0031-9422. https://doi.org/10.1016/0031-9422(89)80209-2