(Aquifoliaceae) Ilex rotunda Thunb.

Local name(s): ໂທນ ຫັນ ແດງ (tohn han daeng)

Medicinal use(s): treat infections (esp. external)

Part used: stem

Field characters: Small tree, leaves alternate, ovate, serrate, fruits red to dark purple-red on short pedicels.

Locality: Xiengkhouang Province, Kham District, Xiengkhouang Medicinal Biodiversity Preserve, mountain road between Muang Kham and Ban Tha. 

Habitat: Roadside. Good quality secondary forest, on a mountain slope.

Altitude:  1137 m asl

Collector(s): J.M. Henkin, K. Sydara, M. Xayvue, D.D. Soejarto

Collection number: JMH 018

Collection date: December 9, 2015

Additional information:  

Voucher specimen is in deposit at the Field Museum (F) Herbarium, Chicago, USA under accession no. 2320620.

Synonyms, images, taxonomic description:  

Plants of the World onlineFlora of China Vol. 11 Page 360, 381 

Useful references: 

Henkin, JM et al. J Med Plant Res. 2017 Oct; 11(40): 621–634. 
Chen G, Han Y, Feng Y, Wang A, Li X, Deng S, Zhang L, Xiao J, Li Y, Li N. Extract of Ilex rotunda Thunb alleviates experimental colitis-associated cancer via suppressing inflammation-induced miR-31-5p/YAP overexpression. Phytomedicine. 2019 Sep;62:152941. doi: 10.1016/j.phymed.2019.152941. Epub 2019 Apr 30. PubMed PMID: 31100679.
Han Y, Zhang L, Li W, Liu X, Xiao J, Chen G, Li N. Natural CAC chemopreventive agents from Ilex rotunda Thunb. J Nat Med. 2019 Jun;73(3):456-467. doi: 10.1007/s11418-019-01281-z. Epub 2019 Feb 13. PubMed PMID: 30758715.
Liu C, Shen YJ, Tu QB, Zhao YR, Guo H, Wang J, Zhang L, Shi HW, Sun Y. Pedunculoside, a novel triterpene saponin extracted from Ilex rotunda, ameliorates high-fat diet induced hyperlipidemia in rats. Biomed Pharmacother. 2018 May;101:608-616. doi: 10.1016/j.biopha.2018.02.131. Epub 2018 Mar 22. PubMed PMID: 29518607.
Yang B, Li H, Ruan QF, Xue YY, Cao D, Zhou XH, Jiang SQ, Yi T, Jin J, Zhao ZX. A facile and selective approach to the qualitative and quantitative analysis of triterpenoids and phenylpropanoids by UPLC/Q-TOF-MS/MS for the quality control of Ilex rotunda. J Pharm Biomed Anal. 2018 Aug 5;157:44-58. doi: 10.1016/j.jpba.2018.05.002. Epub 2018 May 3. PubMed PMID: 29758469.