(Apocynaceae) Cryptolepis dubia (Burm.f.) M.R.Almeida

Local name(s): (Kheua en one) 

Medicinal use(s): treat nervous system disorders

Part(s) used: vine

Field Characters: Vine, flowers gtrenish yellow to pale yellow, latex milky white.

Locality: Xieg Khouang Province, Kham District, Kham Medicinal Bodiversity Preserve, 15 km from Kham town.

Habitat: Broadleaved evergreen submomtane forest. Edge of forest along road.

Altitude: 1130 m asl. 

Collector(s): D.D. Soejarto, K. Sydara, M. Xayvue 

Collection number(s): DDS 14971

Collection Date: May 16, 2014

Additional information:  

Voucher specimen is in deposit at the Field Museum (F) Herbarium, Chicago, USA under accession no. 2313845.

Synonyms, images, taxonomic description: 


Plants of the World onlineFlora of China Vol. 16 Page 193 (under syn. Cryptolepis buchananii )Usefl Tropical Plant: Cryptolepis dubiaiGlobal Biodiversity Information Facility

Medicinal properties:

Henkin JM, Sydara K, Xayvue M, et al. (2017). Revisiting the linkage between ethnomedical use and development of new medicines: A novel plant collection strategy towards the discovery of anticancer agents. Journal of Medicinal Plant Research 2017, 11(40), 621-634. https://doi.org/10.5897/JMPR2017.6485

Ren Y, Kaweesa EN, Tian L, et al. The Cytotoxic Cardiac Glycoside (−)-Cryptanoside A from the Stems of Cryptolepis dubia and Its Molecular Targets. Journal of Natural Products 2023 86 (6). 14. DOI: 10.1021/acs.jnatprod.3c00094

Ren Y, Kaweesa EN, Henkin JH, et al. Cytotoxic leuconoxine-type diazaspiroindole alkaloids isolated from Cryptolepis dubia. Bioorganic & Medicinal Chemistry Letters 2024, volume 101, 129650. ISSN 0960-894X. https://doi.org/10.1016/j.bmcl.2024.129650. 

Sriset, Y  Pharmacological Activities of Cryptolepis dubia (Burm.f.) M.R.Almeida. Isan Jurnal of Pharmaceutical Sciences 2017,  vol. 13, no. 1 (2017): DOI: https://doi.org/10.14456/ijps.2017.1 
Useful Tropical Plants. Cryptole[is dubia (Burm.f.) M.R.Almeida.  Cryptolepis+dubia. https://tropical.theferns.info/viewtropical.php?id=Cryptolepis+dubia 

Venkateswara R, Narendra N, Viswamitra MA, et al. Cryptosin, a cardenolide from the leaves of Cryptolepis buchanani. Phytochemistry 1989, volume 28, issue 4, pages 1203-1205. ISSN 0031-9422. https://doi.org/10.1016/0031-9422(89)80209-2